Moreover, previous work has found that parvalbumin-expressing (PV) inhibitory interneurons, which play a critical role in auditory cortical gain control, adaptation and recurrent excitation [42], are abnormally sparse in the auditory cortex of Df1/+ mice—and this PV interneuron deficit correlates with degree of hearing impairment [22]. The gene discussed is YTHDF1; the disease is Hearing impairment.