Df1/+ mice exhibited 3 key AEP abnormalities: (1) increased central auditory gain, which was especially pronounced for stimulation of ears with hearing impairment; (2) increased growth of AEP amplitude with sound level, regardless of the presence or absence of hearing impairment in the stimulated ear; and (3) increased growth of AEP amplitude with inter-stimulus-interval duration when hearing was normal in the stimulated ear. Here, YTHDF1 is linked to hearing loss disorder.