In summary, these results show that Df1/+ mice have abnormalities in central auditory gain (AEP/ABR ratio) that are exacerbated by hearing impairment; abnormalities in central auditory excitability (level-dependent AEP amplitude growth) that are robust to hearing impairment; and abnormalities in auditory adaptation (interval-dependent AEP amplitude growth) that are either counteracted or masked by hearing impairment. Here, YTHDF1 is linked to Hearing impairment.