CBLN1 has been found to be up-regulated in neuron-like cells derived from C9-ALS patients67,68, a finding we corroborated by qPCR, which showed a ~14-fold increase in its expression in the C9-ALS iMNs versus the wild-type cells (P < 0.0001; Fig. 3k). The gene discussed is C9; the disease is amyotrophic lateral sclerosis.