MYC and cancer: The TI cell cluster was markedly enriched for YAP, mTORC1, E2F, and MYC-driven programs, and modules defining pan-cancer cell states53 including pEMT, hypoxia, cell cycle, interferon response, and squamous differentiation (Fig. 4f, Supplementary Fig. 6f), suggesting key oncogenic pathways were exclusively activated in TI cells.