The TI cell cluster was markedly enriched for YAP, mTORC1, E2F, and MYC-driven programs, and modules defining pan-cancer cell states53 including pEMT, hypoxia, cell cycle, interferon response, and squamous differentiation (Fig. 4f, Supplementary Fig. 6f), suggesting key oncogenic pathways were exclusively activated in TI cells. Here, YAP1 is linked to cancer.