WWTR1 and neoplasm: To investigate whether YAP-mediated mTOR activation contributed to tumor initiation, we treated KEY primary cells with siRNAs targeting Yap/Taz and Tead1/Tead4 as well as small molecule mTOR (INK128) and YAP-TEAD (VT104) inhibitors, and observed significant reductions in clonogenic growth (Supplementary Fig. 9j-k).