S100B and Encephalopathy: After multivariable regression models the variables that contributed to worsening of mRS were MV vs no O2 therapy (OR = 9.56, 95% CI = 1.67–54.75; p = 0.011), severe encephalopathy vs COVID-w/o Neuro (OR = 5.10, 95% CI = 1.58–16.19; p = 0.006), S100B (per 1-μg/mL increase OR = 2.62, 95% CI = 1.10–6.46; p = 0.037) and duration of admission (per 1-day increase OR = 1.03, 95% CI = 1.01–1.05; p = 0.001).