Key predictors of worsening mRS included mechanical ventilation (OR = 9.56, 95% CI = 1.67–54.75; p = 0.011), severe encephalopathy (OR = 5.10, 95% CI = 1.58–16.19; p = 0.006), and elevated S100B levels (OR = 2.62, 95% CI = 1.10–6.46; p = 0.037). Here, S100B is linked to Encephalopathy.