Hepatocyte-specific ROCK1 knockout mice on the FFC diet decreased liver steatosis, hepatic cell death, liver inflammation, and fibrosis compared with wild type littermate FFC-fed controls and attenuated myeloid cell recruitment, which was secondary to the hepatocyte actions because myeloid cell-specific ROCK1 deletion did not affect NASH development in FFC-fed mice. Here, ROCK1 is linked to Hepatic steatosis.