By transfecting the MiR206‐3p sponge to reduce the level of MiR206‐3p in AAA, the effects of the CXCL12/CXCR4 pathway on AAA progression as well as the apoptosis and phenotypic transformation of vascular smooth muscle cells (VSMCs) were studied in vivo and in vitro. The gene discussed is CXCR4; the disease is triple-A syndrome.