Notably, the C‐X‐C Motif Chemokine Ligand 12/C‐X‐C Chemokine Receptor Type 4 (CXCL12/CXCR4) signalling pathway's activation is markedly increased in a mouse model of abdominal aortic aneurysms (AAA). The gene discussed is CXCL12; the disease is triple-A syndrome.