ZBTB11 activates the transcription of DDX1 by binding to its promoter region, and Knockdown of ZBTB11 increases R‐loop accumulation and DNA damage, thereby inhibiting the growth of bladder cancer cells [75], the R‐loop interacts with chromatin remodelling complexes to regulate the stability of the genome [73], in bladder cancer, multiple subunits of chromatin remodelling complexes undergo mutations and are closely associated with cell proliferation and tumour progression. The gene discussed is DDX1; the disease is urinary bladder cancer.