Research has found that STM2457 can inhibit the catalytic activity of METTL3/METTL14, targeting populations of acute myeloid leukaemia (AML) key stem cells with an IC50 = 16.9 nM and it is identified as a specific METTL3 inhibitor [187]. The gene discussed is METTL14; the disease is acute myeloid leukemia.