GRIA2 and Cognitive impairment: However, for 3-month-old APP/PS1-mice, the age where cognitive impairments arise (Vegh et al., 2014; Reinders et al., 2016), GluA3 levels were decreased significantly more than GluA1 and GluA2 levels in APP/PS1-mice compared with those in the wild-type (Fig. 7B).