Furthermore, the spatial pattern of tau PET often matches brain regions that are clinically affected and show evidence of neurodegeneration on FDG PET or MRI (e.g., greater involvement of occipital visual processing regions in PCA, greater left hemisphere involvement in lvPPA, and greater binding in the sensorimotor cortex in CBS due to AD) (61,182–184), increasing confidence that the underlying syndrome is due to AD. The gene discussed is MAPT; the disease is Alzheimer disease.