Alzheimer’s disease (AD) is defined neuropathologically by the deposition of extracellular plaques composed of aggregated forms of the amyloid-beta (Aβ) polypeptide and intraneuronal neurofibrillary tangles (NFTs) composed of aggregated hyperphosphorylated tau protein (1,2). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.