Infection of the DicerO-3 line at MOI 0.01 showed a statistically significant reduction of LCMV RNA by 26.9% (Figure 8A) and an increased abundance of LCMV-derived 21–23-nt RNAs in DicerO-3 ESCs, which was ∼10× higher than in the DicerΔ HEL1/ Δ HEL1 ESCs (Figure 8B and C versus 7C and D). The gene discussed is SMARCAD1; the disease is infection.