We also observed genes with gene-based P-values ≤ 0.01 not before linked to AD, which are likely to contribute to AD risk given their co-expression with other genes enriched for AD risk, namely, APOC2, ARHGAP45, ATP8B4, CMTM7, COX7A1, DOK3, MARCO, NOP2, PCED1B and TMC8 (Table 1 and Supplementary Tables 1 and 4). The gene discussed is TMC8; the disease is Alzheimer disease.