KNOP1 and Alzheimer disease: We identified two additional loci containing FURIN and FES genes (CHR15:91411822–91439006, PFDR = 9.8 × 10−4 and 2.06 × 10−4, respectively) and KNOP1 and IQCK genes (CHR16:19713256–19869789, PFDR = 3.3 × 10−3 and 3.9 × 10−4, respectively) associated with longevity and AD, respectively.