TREM2 and Alzheimer disease: SNX1 is a member of the sorting nexin family (SNX) that is involved in endosomal protein sorting, and its dysfunction has been linked to neurodegenerative diseases, including AD.61  UNC5CL was also part of the age-dependent oligodendrocyte network but is close to the TREM2 locus and might therefore be linked to TREM2 SNPs.40