TNF and metabolic dysfunction-associated steatohepatitis: It is worth noting that Exo/ASO-TNF failed to reduce IL1β expression in macrophages in vitro (Fig. 3A–C), whereas treatment with Exo/ASO-TNF could decrease IL1β expression in livers or hepatic macrophages from NASH mice (Fig. 3, Fig. 5, Fig. 6).