We previously found that apical infection of a polarized epithelial monolayer by PLY‐producing Sp triggers 12‐lipoxygenase activity and production of the eicosanoid hepoxilin A3 (HXA3), a potent PMN chemoattractant that both promotes PMN transepithelial migration and the release of neutrophil elastase (NE) (Xu et al. 2024), a protease with tissue‐destructive potential (Boxio et al. 2016; Domon and Terao 2021; Ginzberg et al. 2001). Here, ELANE is linked to infection.