CDH1 and bacterial infectious disease with sepsis: To examine the potential role of PLY‐mediated Sp damage to airway epithelial junctions during pulmonary infection, we followed the kinetics of E‐cadherin disorganization, PMN infiltration, barrier disruption, and bacteremia after i.t. challenge of 2‐month‐old BALB/c mice with 1 × 107 CFU of wild‐type (WT) or PLY‐deficient (Δply) Sp.