The results of the two‐sample MR analysis showed that three proteins, TDRKH (OR: 0.6866, 95% CI: 0.4721–0.9987; p = 0.049), THBS4 (OR: 1.6071, 95% CI: 1.1199–2.3063; p = 0.01), and ICA1 (OR: 1.8042, 95% CI: 1.0962–2.9697; p = 0.02), were causally associated with HCC (Figure 4). This evidence concerns the gene ICA1 and hepatocellular carcinoma.