In pancreatic cancer tissues, SIRT2 deacetylates LDHA at the K5 site, preventing its recognition by the HSC70 chaperone and inhibiting its lysosomal degradation, thereby increasing LDHA activity and protein levels, enhancing the Warburg effect and promoting pancreatic cancer cell proliferation and migration.251. This evidence concerns the gene LDHA and familial pancreatic carcinoma.