Under glutamate deprivation and hypoxic conditions, phosphoglycerate kinase 1 (PGK1) is acetylated at lysine 388 by NAA10/ARD1, which subsequently leads to the interaction of PGK1 with Beclin 1, causing phosphorylation of Beclin 1 at serine 30, thereby inducing autophagy and brain tumour formation.233, 234. The gene discussed is BECN1; the disease is brain neoplasm.