HDAC11 expression is elevated in HCC, where it inhibits the transcription of LKB1 by suppressing histone acetylation in the promoter region of LKB1, thereby silencing the AMPK signalling pathway and activating mTORC1 activity and glycolysis, leading to stem cell properties and the progression of HCC.68 The gene discussed is STK11; the disease is hepatocellular carcinoma.