Under the stimulation of growth factors, HDAC3 interacts with the scaffold protein APPL to promote deacetylation of AKT at lysines 14 and 20, leading to polyubiquitination and phosphorylation of AKT, activation of the AKT–mTOR signalling pathway, and promotion of prostate cancer cell growth.49 The gene discussed is AKT1; the disease is prostate cancer.