c‐myc promotes the degradation of SIRT3 deacetylase mediated by the cell cycle regulatory protein SKP2, leading to acetylation‐dependent inactivation of succinate dehydrogenase complex subunit A at K335, resulting in succinate accumulation in cells and triggering H3K4me3 activation and tumour‐specific gene expression, thereby promoting tumour growth.263. This evidence concerns the gene SKP2 and neoplasm.