A protein isolated from bitter melon seeds, MCP30, can inhibit HDAC‐1 activity, promote the acetylation of histones H3 and H4, increase phosphatase and tensin homolog (PTEN) transcription, inhibit serine/threonine kinase B (Akt) phosphorylation and subsequently induce apoptosis in prostate intraepithelial neoplasia and prostate cancer cell lines.13 Here, HDAC1 is linked to prostate cancer.