HIF1A and neoplasm: Under hypoxia or stimulation by certain cytokines, the expression of the HIF1α subunit significantly increases, and HIF1α enters the nucleus to bind to the HIF1β subunit to form active HIF‐1, which then regulates the transcription of downstream target genes, promoting the expression of glycolysis‐related enzymes and allowing tumour cells to produce energy through glycolysis even under hypoxic conditions,180 while mTORC1 can induce HIF1α expression to increase the expression of glucose transporters and glycolytic genes.181, 182