Lycorine, a flavonoid compound with various biological activities, can directly target the unique C‐terminal domain of IDH1, disrupting the interaction between IDH1 and SIRT1, thereby promoting IDH1 acetylation, inhibiting IDH1 enzymatic activity and inducing oxidative stress, mitochondrial membrane damage and mitochondrial fission in CRC cells.257. The gene discussed is SIRT1; the disease is colorectal carcinoma.