In prostate cancer cells, SIRT1/2 also promotes the multiubiquitination and proteasomal degradation of FoxO3 mediated by the E3 ubiquitin ligase subunit Skp2 by deacetylating FoxO3, thereby down‐regulating FoxO3 protein levels.116. The gene discussed is FOXO3; the disease is Familial prostate cancer.