Notably, in multiple myeloma, although HDAC3 reduces STAT3 acetylation levels, it also promotes the phosphorylation of STAT3 at tyrosine 705 and serine 727, thereby significantly inhibiting tumour cell apoptosis and promoting cell growth, indicating possible crosstalk between acetylation and phosphorylation.107. This evidence concerns the gene HDAC3 and AL amyloidosis.