Acetylation of GDH1 at K527 induces the formation of a GDH1 complex with EGLN1/HIF‐1α, whereas acetylation at K503 enhances its ability to react with α‐ketoglutarate to produce glutamate, increasing the stability of HIF‐1α and promoting the progression of CRC.289. Here, GLUD1 is linked to colorectal carcinoma.