In multiple myeloma and HCC, the ubiquitin ligases SIAH2 and TRAF6 can degrade HDAC3 through ubiquitination, enhancing H3K27 and H3K9 acetylation levels in the c‐myc promoter region and thereby promoting c‐myc transcription.211, 212. This evidence concerns the gene MYC and plasma cell myeloma.