Interestingly, gene ontology analysis of overall up-regulated gene networks (S8C Fig) and up-regulated gene program in infected USP30-AS1-/- cells (K1) (Fig 5B) suggested a group of responses that are similar to bacterial infection, with TLR2 up-regulation around 5-fold in CA04 infected USP30-AS1-/- cells compared to CA04 infected WT cells (Fig 5C). This evidence concerns the gene KRT1 and bacterial infectious disease.