ABCB11 and obesity due to melanocortin 4 receptor deficiency: He found GCKR, ABCB11, CDKAL1, CDKN2B, NT5C2, and APOC1 gene were associated with metabolically unhealthy phenotypes in individuals with normal weight but not in those with obesity, showing that certain genetic polymorphisms may also have an impact on the metabolic health in NWO populations [41].