More specifically, it has been suggested that NFKBIZ is involved in renal fibrosis and, analogically to liver fibrosis leading to hepatocellular carcinoma, we can speculate that NFKBIZ-mediated fibrosis in donor’s kidney may lead to tumor of the transplanted kidney in the recipient, especially when combined with the recipients’ compromised immunosurveillance due to long-term immunosuppressive treatment [53–55]. This evidence concerns the gene NFKBIZ and Hepatic fibrosis.