SDHB and renal cell carcinoma: Recently, it has been estimated that 2–8% of RCC cases are of hereditary origin with identified germline pathogenic or likely pathogenic variants (GPV) in genes including BAP1, FH, FLCN, MET, MITF, PTEN, SDH genes (SDHA, SDHAF2, SDHB, SDHC, SDHD), TSC1, TSC2, VHL, and WT1 [17–22].