RBFOX3 and breast carcinoma: Crocin is a water‐soluble carotene with a potent pharmacological activity that inhibits the production of ROS and suppresses the production of proinflammatory cytokines.[50] In addition, crocin has anti‐migratory, anti‐invasive, and anti‐vasculogenic mimicry capabilities, can substantially attenuate tumor ECM adhesion, and is a potential agent against cancers,[51] such as breast cancer.[52] Crocin can inhibit the production of MLTCs by targeting Rbfox3 and improve the anti‐tumor effect of the PD‐1 antibody, which is expected to be developed as an anti‐tumor drug.