Rbfox3, also known as NeuN, is generally believed to exist in the nuclei of mature neurons, and is considered a clear marker of mature neurons.[48, 49] However, in some cancers, the tumor cells of patients with high Rbfox3 expression show high tumorigenicity and stem cell‐like characteristics with self‐renewal and pluripotent differentiation potential. This evidence concerns the gene RBFOX3 and cancer.