Crocin is a water‐soluble carotene with a potent pharmacological activity that inhibits the production of ROS and suppresses the production of proinflammatory cytokines.[50] In addition, crocin has anti‐migratory, anti‐invasive, and anti‐vasculogenic mimicry capabilities, can substantially attenuate tumor ECM adhesion, and is a potential agent against cancers,[51] such as breast cancer.[52] Crocin can inhibit the production of MLTCs by targeting Rbfox3 and improve the anti‐tumor effect of the PD‐1 antibody, which is expected to be developed as an anti‐tumor drug. This evidence concerns the gene RBFOX3 and neoplasm.