Rbfox3, also known as NeuN, is generally believed to exist in the nuclei of mature neurons, and is considered a clear marker of mature neurons.[48, 49] However, in some cancers, the tumor cells of patients with high Rbfox3 expression show high tumorigenicity and stem cell‐like characteristics with self‐renewal and pluripotent differentiation potential. Here, RBFOX3 is linked to neoplasm.