Specifically, we found that TNF‐β, IL‐16, MIP‐1α, MIP‐1β, IL‐12/23p40, IL‐10, IL‐8, MCP‐1, IL‐17A, IL‐2, IL‐6, IL‐27, GAL‐9, IL‐4, and MIP‐3α were significantly elevated in CLL patients compared to HC (Fig. 6B and Fig. S2B). This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.