Specifically, we found the plasma levels of IL‐27, IL‐6, MIP‐1α, MIP‐1β, MIP‐3α, IL‐15, IL‐17, IL‐16, IL‐22, Gal‐9, and IP‐10 were significantly elevated in CLL patients with higher Rai stage (III/IV) than in those with intermediate (I/II) or low Rai (0) stages (Fig. 6D–G). This evidence concerns the gene IL27 and B-cell chronic lymphocytic leukemia.