In contrast, we found that IL‐4, IL‐13, IL‐7, TARC, and MCP‐4 were significantly reduced in CLL patients with higher Rai stage (III/IV) than in those with intermediate (I/II) or lower Rai (0) stages (Fig. 6D–G). This evidence concerns the gene CCL13 and B-cell chronic lymphocytic leukemia.