However, recent meta‐analysis data have proposed a prognostic model, the International Prognostic Index (CLL‐IPI), based on five independent prognostic factors, such as IgHV, TP53, serum 2‐microglobulin concentration, clinical stage (Rai or Binet), and age older than 65 years [9]. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.