Among elevated cytokines in CLL patients, IL‐16, IL‐6, MIP‐1α (CCL3), and MCP‐1 showed the highest deviation compared to HCs (P < 0.0001), followed by IL‐17A, TNF‐β, IL‐12/23p40, and IL‐2 (Fig. 6B). The gene discussed is IL16; the disease is B-cell chronic lymphocytic leukemia.