BDNF and Cognitive impairment: In addition to the observed surge in the hippocampal markers of neurodegeneration, we found that HFD intake demonstrably lowered hippocampal BDNF levels. Hampering BDNF signaling can restrain synaptic plasticity and curb hippocampal neurogenesis, thereby impairing hippocampal‐dependent learning and memory [2], which implies that the fall in hippocampal BDNF may possibly play a role in the cognitive impairment brought on by high-fat consumption in rats.