HFD intake resulted in dyslipidemia and hyperleptinemia, along with Aβ accumulation, tau hyperphosphorylation, α-synuclein elevation, and BDNF diminishment in the hippocampus, in addition to neurotransmitter and redox imbalance, heightened inflammation, and energy decline in the striatum and hippocampus with subsequent cognitive dysfunction. This evidence concerns the gene MAPT and metabolic syndrome.