The intermediate structure should be dedicated to patients with HF evidence, previous episodes of HF hospitalization, those with frank systolic dysfunction (ejection fraction EF < 40%) or evidence of advanced diastolic dysfunction reflecting HFpEF diagnostic criteria, patients with reduced physical activity in NYHA class > I and those with baseline NP (BNP > 100 and NTproBNP > 400 pg/ml, respectively). The gene discussed is NPPB; the disease is hydrops fetalis.