BGLAP and type 2 diabetes mellitus: Biochemical markers of bone formation (PINP, OC) and bone resorption (CTX) were lower in patients with T2DM compared to controls (P1NP −34.8%, CTX −41.5% and OC −42.0%, p < 0.001) and remained significantly lower after adjusting for age, gender and BMI (Table 2).