PMN-MDSC, M-MDSC (Supplementary Fig. S3C), NK-cell (Fig. 3H), CD4+ T-cell, Treg (Fig. 3I), and macrophage (total, M1-like, or M2-like; Fig. 3J and K) levels in the tumor did not significantly change with IL-12 and/or trabectedin treatment, which is in contrast to the splenic results. The gene discussed is CD4; the disease is neoplasm.