Additionally, a significant increase in immunosuppressive cells such as FoxP3+, CTL4+, ratio of Tregs cells to CD8+ tumor-infiltrating lymphocytes, PDL-1, and PD-1 expression was observed in EBV-positive than EBV‐negative squamous CC cases (15), indicating that EBV-positive tissue may be more susceptible to immunotherapy (21). This evidence concerns the gene CD8A and neoplasm.