SPRY4-IT1 demonstrated a specificity and sensitivity of 89,4% and 72.8% respectively (AUC: 0.842) in the identification of esophageal squamous cell carcinoma (ESCC) when paired with POU3F3 and HNF1AAS1 (112). This evidence concerns the gene POU3F3 and esophageal squamous cell carcinoma.