For example, the expression of GOT1 was suppressed by hypoxia-inducible factor-1α (HIF-1α) in VHL-deficient human renal carcinoma (43), and by electron transport chain (ETC) in human Raji lymphoma and KMS-26 multiple myeloma (38, 53), leading to impaired proliferation of cancer cells. The gene discussed is GOT1; the disease is cancer.