Figure 3E revealed that lipid localization, collagen-containing extracellular matrix and receptor ligand activity were the most enriched BP, CC and MF, respectively. The results of the KEGG enrichment analysis demonstrated that cholesterol metabolism-related DEGs are mainly enriched in pathways such as Staphylococcus aureus infection, complement and coagulation and coronavirus disease-COVID-19(Figure 3F). The gene discussed is CXCR1; the disease is staphylococcus aureus infection.