Utilizing a meticulously selected panel of variables, including smoking status, alcohol consumption, female gender, low educational attainment, NIHSS score at admission, stroke progression, diabetes mellitus, atrial fibrillation, stroke localization, HCY levels, and Lp-PLA2 levels, a clinical prediction model was formulated to predict the occurrence of PSCI within six months of AIS. This evidence concerns the gene PLA2G7 and Stroke.