Moreover, they also found a significant difference according to severity for stroke patients for copeptin (0.0012), renalase (0.0069) and MMP-9 (0.0094): for severe ischemic stroke (National Institutes of Health Stroke Scale (NIHSS) score > 14) compared to moderate ischemic stroke (NIHSS score < 14). The gene discussed is AVP; the disease is ischemic stroke.