After adjusting for age, sex, BMI, SBP, history of hypertension, history of diabetes, history of coronary heart disease, history of stroke, NC, LDL-C, HDL-C, albumin, FPG, Hcy, eGFR, UA, etc., we found a negative association between LCR and CSVD, suggesting that LCR may be an independent protective factor of CSVD. This evidence concerns the gene ALB and hypertensive disorder.