Univariate analysis revealed significant associations (p < 0.05) between CSVD and factors of age, sex, SBP, smoking, alcohol consumption, hypertension, diabetes, coronary heart disease, stroke, NC, Alb, FPG, LDL-C, HDL-C, Hcy, eGFR, UA, and LCR. The gene discussed is ALB; the disease is Stroke.