There were significant differences in age, sex, SBP, history of hypertension, diabetes, coronary heart disease, stroke, NC, lymphocyte counts, CRP, Alb, FPG, LDL-C, HDL-C, Hcy, eGFR, and UA between CSVD and non-CSVD groups (p < 0.05). The gene discussed is ALB; the disease is Hypertension.