Notably, phase separation plays a crucial role in modulating the activity of the target of Rapamycin Complex 1 (TORC1): the suppression of TORC1 signalling triggers the initiation of autophagy, and dysregulation of both TORC1 and autophagy has been implicated in the development of tumours (Noda et al., 2020). This evidence concerns the gene CRTC1 and neoplasm.