MAPT and Alzheimer disease: Furthermore, some studies have revealed a significant accumulation of phosphorylated tau in GABAergic interneurons of the dentate gyrus in Alzheimer’s disease patients, which subsequently inhibits GABAergic transmission and disinhibits the neural circuitry within the neurogenic niche, thereby impairing adult hippocampal neurogenesis and leading to cognitive decline in Alzheimer’s disease (Zheng et al., 2020).