KEGG pathway enrichment analysis revealed that DEGs were mainly involved in pathways related to neurodegeneration-multiple diseases, amyotrophic lateral sclerosis, Alzheimer’s disease, prion disease, the PI3K-Akt signaling pathway, the AMPK signaling pathway, and the Foxo signaling pathway (Figure 2B). The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.