KL and chronic kidney disease: Additionally, hypertension status produced an intriguing significant interaction whereby in patients with hypertension, every 1-pg/mL increase in log2 Klotho was associated with a 43% decrease in CKD risk, while in individuals with no hypertension, every 1-pg/mL increase in log2 Klotho was associated with a 9% increase in CKD risk (Pinteraction =0.006) (Figure 4B).