Rearranged during transfection (RET) is a neuronal growth factor receptor tyrosine kinase critical for the development of the enteric nervous system (ENS), which may lead to the hyperinnervation of visceral afferent neurons in the GI tract and contribute to the pathophysiology of IBS (Schenck Eidam et al., 2018). The gene discussed is NTRK1; the disease is irritable bowel syndrome.