The 25 most important signaling pathways included IFN-γ signaling, interferon alpha/beta signaling, macrophage classical activation signaling pathway, pathogen-induced cytokine storm signaling pathway, role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza, IL-4 and IL-13 signaling, interferon signaling, protein ubiquitination pathway, antigen presentation pathway, and unfolded protein response. This evidence concerns the gene IL13 and influenza.