However, they may also promote tumor progression through GAS6-AXL and ANXA1-FPR1 signaling, interacting with fibroblasts, endothelial cells, and monocytes, while the role of MDK-SDC2 and MDK-(ITGA4+ITGB1) signals remains to be elucidated. The gene discussed is GAS6; the disease is neoplasm.