(131) used TC-derived microenvironmental culture systems and patient-derived xenograft (PDX) models to explore and found that thyroid cancer stromal cells promoted TCSCs sphere formation, clonal proliferation, and invasiveness of TCSCs through mediating JAK/STAT3 and PI3K/Akt transduction of signaling in TCSCs. This evidence concerns the gene AKT1 and thyroid gland carcinoma.