SOX2 and thyroid gland carcinoma: It was observed that when UHRF1 was knocked down in thyroid cancer cells, not only markers of cellular dedifferentiation (e.g., CD97) were significantly decreased, but also stem cell-associated markers (Sox2, Oct4, and Nanog) were significantly reduced at both mRNA and protein levels, suggesting that down-regulation of UHRF1 expression could promote thyroid cancer cell differentiation at the transcriptional level, which is important for the containment of invasive thyroid cancer (ATC) development (145).