CXCL8 and thyroid cancer: Several studies have indicated that TC cells’ generation of reactive oxygen species or inflammatory signals can cause MCs to release TNF-α, IL-6, and IL-8, which in turn encourages the EMT process in thyroid cancer cells’ TC subtypes (FTC, ATC, and PTC) (63, 111); The creation of TCSCs may require the activation of EMT, a highly complicated cell biology process that controls cellular plasticity and activates a number of signaling pathways linked to stemness (28).