SIGLEC15 belongs to the salivary acid-binding immunoglobulin-like lectin family gene family (125)and is an immunosuppressive factor produced by tumor-infiltrating myeloid cells as well as by specific tumor cells that is mutually exclusive with PD-L1 (126), and may bind to TLR2 and inhibit the activation of CD8+ T cells, suggesting that SIGLEC15-TLR2 interacts to transmit inhibitory signals and downregulate T cell immune responses (127). This evidence concerns the gene CD8A and neoplasm.