It was observed that when UHRF1 was knocked down in thyroid cancer cells, not only markers of cellular dedifferentiation (e.g., CD97) were significantly decreased, but also stem cell-associated markers (Sox2, Oct4, and Nanog) were significantly reduced at both mRNA and protein levels, suggesting that down-regulation of UHRF1 expression could promote thyroid cancer cell differentiation at the transcriptional level, which is important for the containment of invasive thyroid cancer (ATC) development (145). The gene discussed is SOX2; the disease is thyroid cancer.