When exposed to IL-4, IL-13, TGF-β, and other signals macrophages are induced to transform into a further class of M2-like TAM promoting tumor cell proliferation, stromal remodeling, neovascularization, and tumor niche modulation and interaction with CSCs contributes to the formation of immunosuppressive TME (81, 82). This evidence concerns the gene TGFB1 and neoplasm.