Among them, TD CD4+ %T cell (OR = 0.430, 95% CI 0.195–0.947, p = 0.036) and CD39+ CD8br %T cell (OR = 0.173, 95% CI 0.055–0.541, p = 0.003) may mitigate the risk of AMD, while CD39+ CD8br %CD8br (OR = 5.715, 95% CI 1.611–20.273, p = 0.007) and CD45RA on resting Treg (OR = 2.872, 95% CI 1.046–7.884, p = 0.041) are more likely to be risk factors for AMD (refer to Table 4 and Figure 3). This evidence concerns the gene ENTPD1 and age-related macular degeneration.