Subsequent studies revealed that in untreated patients with nephrotic syndrome, fasting plasma ANGPTL4 levels significantly increased with a higher free fatty acid-to-albumin ratio, occurring not only in MCD but also in focal segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN) 19. This evidence concerns the gene ANGPTL4 and membranous glomerulonephritis.