Simultaneously, compared to the AD+PBS mice, hDPSCs significantly enhanced the mRNA and protein expression of Wnt8b, β-catenin and their downstream molecules (TCF4, c-Myc, and Cyclin-D1), and decreased the expression of β-catenin destruction complex (Axin2 and GSK-3β) in the hippocampus (Figure 5D-F). This evidence concerns the gene TCF4 and Alzheimer disease.