We observed that reduced microglia activation occurred in the form of a transformation from a reactive state to a more homeostatic or surveillance state, and a reduction in the CD68-marked area in plaques in the hDPSCs-treated AD mice was readily appreciable as compared to the AD+PBS mice group (Figure 2C, D), implying the ability of hDPSCs administration to convert plaque size and structure to a more indolent state. The gene discussed is CD68; the disease is Alzheimer disease.