WNT8B and Alzheimer disease: Considering that transplanted hDPSCs can spontaneously differentiate into neurons within a short term and that secretion of Wnt8b activates the canonical Wnt signaling pathway to promote hippocampus neural regeneration, we wondered whether human-derived neurons and cells could survive in 3xTg-AD mice for a long term with similar Wnt signaling activation in the hippocampus.