MAPT and Alzheimer disease: Alzheimer's disease (AD), the most prevalent age-dependent neurodegenerative disorder, is characterized by progressive cognitive dysfunction concomitant with several typical neuropathological hallmarks: extracellular amyloid-β (Aβ) deposits, intracellular neurofibrillary tangles (NFTs) arising from the accumulation of truncated and hyperphosphorylated tau protein, neuroinflammation, and neuronal loss 1.