Surprisingly, fluorescence analysis showed a significant reduction in the relative fluorescence intensity of p-Tau (Ser396 and AT8) in the hippocampus of the hDPSCs-treated mice compared to AD+PBS mice; the relative fluorescence expression of p-Tau (Ser396) in the hippocampus of hDPSCs-treated mice was even lower than that of WT mice (Figure 6I, J and S17). Here, MAPT is linked to Alzheimer disease.