Also, the biomimetic carriers could be further engineered with HCC targeting ligand to enhance the HCC targeting efficacy, such as our team reported that transferrin displayed 293T cell membrane-coated EV and NGR peptide expressed red blood cell membrane-coated EV exhibited much higher HCC accumulation than the non-engineered EV 128, 129. The gene discussed is RTN4R; the disease is hepatocellular carcinoma.