On the contrary, owing to slow-release profile of Nano-IFNγ/Zole in gel, its intratumoral administration resulted in negligible effects on serum level of proinflammatory cytokines, whereas significantly higher amount of IFNγ, CXCL10, CCL2, IL-6, TNF-α and IL-12p70 were detected inside the tumor tissue, which was requisite for tumor recession. Here, IFNG is linked to neoplasm.