The proportion of patients from the BRAF inhibitor alone treatment group who had a high-grade CAEs compared with the BRAF and MEK inhibitor treatment group were 29.02% vs. 4.98% for palmoplantar erythrodysaesthesia syndrome and 19.86% vs. 6.98% for palmoplantar keratoderma. The gene discussed is MAP2K7; the disease is epidermolytic palmoplantar keratoderma, 1.