(4) In contrast with the risk of all-grade rash, alopecia, and palmoplantar keratoderma, the risk of high-grade rash, alopecia, palmoplantar keratoderma, and photosensitivity reaction were similar between the BRAF and MEK inhibitor therapy and BRAF inhibitor monotherapy. This evidence concerns the gene MAP2K7 and epidermolytic palmoplantar keratoderma, 1.