(4) In contrast with the risk of all-grade rash, alopecia, and palmoplantar keratoderma, the risk of high-grade rash, alopecia, palmoplantar keratoderma, and photosensitivity reaction were similar between the BRAF and MEK inhibitor therapy and BRAF inhibitor monotherapy. The gene discussed is BRAF; the disease is hereditary palmoplantar keratoderma.