Liu et al. (2020) demonstrated that GAS markedly influenced apoptotic factors and impeded neuronal apoptosis by reducing the expression of TNF-α, IL-1β, malondialdehyde (MDA), 8-hydroxydeoxyguanosine and 3-nitrotyrosine in the vicinity of hematoma following a collagenase-induced HS model in rats with HS. This evidence concerns the gene IL1B and histiocytic sarcoma.