Furthermore, Liu B. et al. (2018) found that oral administration of GAS inhibited autophagy and apoptosis in neurons of a VD rat model by modulating the deposition of Aβ protein and inhibiting the expression of autophagy-associated proteins Beclin-1 and Light Chain 3 (LC3)-II, as well as the activity of apoptotic factors b-cell lymphoma (Bcl)-2 and p-P38 mitogen-activated protein kinase (MAPK). This evidence concerns the gene BECN1 and sexually transmitted disease.