Hsp90 also interacts with intrinsically disordered proteins that are hallmarks of certain diseases, particularly Tau and amyloid β in Alzheimer’s disease (AD) as well as α-synuclein in Parkinson’s disease (PD) (Okusha et al., 2022; Kakimura et al., 2002; Tiwari et al., 2022; Weickert et al., 2020). Here, HSP90AA1 is linked to Alzheimer disease.