SYNCRIP and Neurodevelopmental delay: Mutations in genes involved in RNA metabolism and gene expression regulation, particularly those from the hnRNP family, are common in NDD patients.[14, 54] In NDD research, Syncrip, a member of the hnRNP family, has been identified as a critical gene associated with NDDs.[7, 12, 13, 14, 55] Mutations in Syncrip are often de novo and significantly enriched in NDD patients.