SYNCRIP and Global developmental delay: These mutations include likely gene‐disruptive (LGD) and missense mutations, affecting its normal role in neurodevelopment.[14] Patients with Syncrip mutations exhibit NDD phenotypes, including developmental delay, ID, ASD, seizures, and structural brain abnormalities.[7, 12, 13, 14, 55] We utilized Syncrip cKO mice to model the phenotypes observed in patients with Syncrip mutations, including learning and spatial memory impairments.