Given the fact that hair cell stereocilia bundles sit on the cuticular plate and are immersed in endolymph, injecting AAV into the endolymph may be expected to have high infection efficiency in sensory hair cells in neonatal and adult mice,[14, 22, 63] although the relative position of the cochlear aqueduct changes with development and may also modulate distribution.[64] Supporting the idea that AAVR localization influenced AAV infection is a study using human airway epithelia in which AAV has higher infection efficiency in the basolateral side of the cells where AAVR is localized.[50]. This evidence concerns the gene KIAA0319L and infection.